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GHRH analog. 20mg lyophilized powder per vial.
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Tesamorelin
What It Is
Tesamorelin is a GHRH analog — it tells your pituitary to release more of your own growth hormone naturally. It's the only GHRH compound to get FDA approval (2010), specifically for reducing belly fat in HIV patients. The key advantage over injecting HGH directly: tesamorelin preserves your body's natural pulsatile GH pattern and feedback loops instead of overriding them.
How It Works
Your pituitary releases GH in pulses, not continuously. Tesamorelin triggers those pulses by activating the GHRH receptor — the same receptor your hypothalamus uses naturally. The result is more GH, but in the natural rhythm your body expects. IGF-1 and somatostatin feedback loops stay intact, reducing the risk of supraphysiological levels that come with direct HGH injection.
What The Research Shows
FDA-approved based on a 15.4% reduction in trunk fat over 26 weeks — that's visceral fat, the dangerous kind.
It raises IGF-1 to normal levels, not supraphysiological ones — a meaningful safety distinction from exogenous HGH.
Ongoing research for fatty liver disease (NAFLD) shows significant liver fat reduction.
Effects maintained over 52 weeks without the body developing tolerance — the pituitary kept responding.
Sources
Tesamorelin for the Treatment of Trunk Fat Accumulation in HIV-Infected Individuals
Falutz J et al. — N Engl J Med, 2007 · PubMed
Information derived from published preclinical and clinical research. Provided for educational purposes only — not medical advice.
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