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Amylin analog. 5mg lyophilized powder per vial.
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Cagrilintide
What It Is
Cagrilintide is a long-acting amylin analog from Novo Nordisk. Amylin is a hormone co-secreted with insulin from your pancreas after eating — it helps regulate blood sugar and appetite through pathways completely separate from GLP-1. Think of it as the "forgotten" satiety hormone. Cagrilintide is engineered for once-weekly dosing.
How It Works
Activates amylin receptors (calcitonin receptor + RAMP proteins), which suppress glucagon after meals, slow gastric emptying, and act on brainstem appetite centers. These pathways are additive with GLP-1 — meaning cagrilintide and semaglutide together produce more appetite suppression than either alone.
What The Research Shows
Up to 10.8% weight loss as monotherapy over 26 weeks.
Designed specifically to combine with semaglutide (CagriSema) for additive effect.
Well-tolerated with GI side effects as the most common complaint.
Sources
Once-weekly cagrilintide for weight management in people with overweight and obesity
Lau DCW et al. — Lancet, 2021 · PubMed
Information derived from published preclinical and clinical research. Provided for educational purposes only — not medical advice.
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