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Mitochondrial-derived peptide. 40mg lyophilized powder per vial.
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MOTS-c
What It Is
MOTS-c is a peptide your mitochondria produce — not your DNA, your mitochondria. That alone makes it unusual. Discovered in 2015, it acts as an exercise mimetic — it activates many of the same metabolic pathways that exercise does. Think of it as your mitochondria sending a signal to the rest of your body saying "we need to burn more fuel and build more capacity."
How It Works
MOTS-c activates AMPK, the master energy sensor in every cell. AMPK activation promotes glucose uptake, fat burning, and mitochondrial biogenesis — the same things exercise triggers. Under metabolic stress, MOTS-c actually moves from the mitochondria into the cell nucleus to directly regulate gene expression. Circulating levels decline with age, correlating with metabolic dysfunction.
What The Research Shows
MOTS-c prevented obesity and insulin resistance in mice fed a high-fat diet — without changing their food intake.
It improved exercise performance in both young and old mice — genuine exercise mimetic effects.
Levels decline with age and are inversely correlated with metabolic disease markers.
Human muscle cell studies confirmed it enhances glucose uptake and metabolic flexibility.
Sources
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline
Reynolds JC et al. — Nat Commun, 2021 · PubMed
Information derived from published preclinical and clinical research. Provided for educational purposes only — not medical advice.
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