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Triple agonist (GIP/GLP-1/glucagon). 30mg lyophilized powder per vial.
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Retatrutide
What It Is
Retatrutide is the triple threat — it hits GIP, GLP-1, AND glucagon receptors all at once. It's the first triple agonist to reach large clinical trials. The glucagon piece is the game-changer: it ramps up your body's energy expenditure and forces your liver to burn more fat. Early trial data produced the highest weight loss numbers ever seen in a controlled study.
How It Works
Three receptors, three effects. GLP-1 kills your appetite and slows digestion. GIP improves fat cell metabolism and insulin handling. Glucagon — the new addition — tells your liver to burn fat for fuel and cranks up thermogenesis (heat production = calories burned). The glucagon component is why retatrutide may cause more weight loss than even tirzepatide — it literally increases how many calories you burn at rest.
What The Research Shows
Phase 2 data showed up to 24.2% weight loss at 48 weeks at the highest dose — the most ever recorded in a controlled obesity trial at publication.
Up to 86% of participants normalized their liver fat levels. That's an extraordinary result for fatty liver.
Currently in Phase 3 trials (TRIUMPH program). If results hold, this becomes the most potent weight loss compound available.
Side effects are similar to other GLP-1 drugs — mostly GI (nausea, diarrhea), worst in the first weeks, improving with dose titration.
Sources
Triple-Hormone-Receptor Agonist Retatrutide for Obesity
Jastreboff AM et al. — N Engl J Med, 2023 · PubMed
Information derived from published preclinical and clinical research. Provided for educational purposes only — not medical advice.
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